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Its half maximal inhibitory concentration (IC50) for GIPR is 42.4 nM, and its EC50 for GLP-1R is 24.4 pM in a human cell-based functional assays (74)
Considering that most current pharmacological treatments of obesity are linked to major side effects, the preclinical research into 5-amino-1MQ looks promising
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Thus, the administration of GLP-1RAs may be the most promising method of treating patients at risk of stroke or immediately after a stroke, although further studies are undoubtedly needed to confirm the effect of GLP-1RAs on stroke risk in patients with T2DM
A similar mechanism has been observed in alcohol-induced steatohepatitis
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